Management and subsequent pregnancies. Other causes of TMA in pregnancy. References 1. McCrae KR. Thrombocytopenia in pregnancy. How I treat thrombocytopenia in pregnancy. Clinical Practice Guide on Thrombocytopenia in Pregnancy. Practice bulletin no. Obstet Gynecol. Analysis of pregnancies in women with 13 different forms of inherited thrombocytopenia. Tosetto A, Castaman G.
How I treat type 2 variant forms of von Willebrand disease. Clinical features and outcome of pregnancy with SLE-associated thrombocytopenia. J Matern Fetal Neonatal Med. Schreiber K, Hunt BJ. Pregnancy and antiphospholipid syndrome. Semin Thromb Hemost. Thrombocytopenia at delivery: a prospective survey of deliveries. Am J Obstet Gynecol. Platelet count at term pregnancy: a reappraisal of the threshold. Causes of thrombocytopenia in triplet gestations. Gestational thrombocytopenia and pregnancy-induced antithrombin deficiency: progenitors to the development of the HELLP syndrome and acute fatty liver of pregnancy.
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Nationwide study of idiopathic thrombocytopenic purpura in pregnant women and the clinical influence on neonates. Int J Hematol. Effect of pregnancy on the course of immune thrombocytopenia: a retrospective study of pregnancies in 82 women. Br J Haematol. The risk of spinal haematoma following neuraxial anaesthesia or lumbar puncture in thrombocytopenic individuals. Intravenous anti-D as a treatment for immune thrombocytopenic purpura ITP during pregnancy.
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Abstract Use of a thrombopoietin mimetic for chronic immune thrombocytopenic purpura in pregnancy. Rescue therapy with romiplostim for refractory primary immune thrombocytopenia during pregnancy.
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Syncytiotrophoblast extracellular vesicles from pre-eclampsia placentas differentially affect platelet function.
PLoS One. Maternal extracellular vesicles and platelets promote preeclampsia via inflammasome activation in trophoblasts. Mao M, Chen C. Corticosteroid therapy for management of hemolysis, elevated liver enzymes, and low platelet count HELLP syndrome: a meta-analysis. Med Sci Monit. Exp Hematol. Sibai BM. Diagnosis, controversies, and management of the syndrome of hemolysis, elevated liver enzymes, and low platelet count. LeFevre ML; U. Preventive Services Task Force.
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Search Page. Hemodynamic management is necessary in severe disease to prevent maternal com- plications The significant higher volume of Conclusions platelet and lower volume of RBC in hypertension in As stated in this review, platelets functions and their im- pregnancy, may indicate the severity of disease.
Inadequate cytotrophoblast in- haematological markers such as MPV and coagulation vasion may constitute the impetus to endothelial cell markers may be associated to Doppler velocimetry, dysfunction and increased activation of platelets.
It is keeping in mind also that the incidence of complications well known that there is platelets consumption because is increased in women who have heritable platelet func- of uncontrolled intravascular platelets activation and fib- tion disorders. In- creased platelets turnover and consequently more im- mature platelets in the maternal circulation may explain References why MPV is increased. Hoak JC. Platelet and atherosclerosis. Semin sociation with hypertensive states 9, Although ThrombHemost.
White JG. Platelets and atherosclerosis. Eur J Clin widespread maternal endothelial dysfunction, interest Invest. Falk E, Fernandez-Ortiz A. Role of thrombosis in the pathophysiology of hypertension in pregnancy. George JN. A reliable plasma mar- uteroplacental circulation with resultant reduction in the ker of platelet activation: does it exist? Am J Hema- number of circulating platelets in the first phase of the tol.
Subsequently, there may be a compensatory Platelet activation: as- increase in bone marrow production. In fact, there is ev- sessment and quantification. Eur Heart J ; idence that in hypertension in pregnancy, the platelets Berkant, Akcit F.
The with normal pregnancies 29, Young platelets thrown mean platelet volume in patients with essential and in circulation are bigger and present a higher tendency white coat hypertension.
Other studies showed previously that Piazze et al. Platelet activation and thrombosis: studies gnancies. Arch Gynecol Obstet. Am J Platelet Hematol ; The use of sia. The main concerns are the high costs and a small risk of Neisseria infection, requiring vaccination prior to treatment Regular plasma exchange and serial monitoring of ADAMTS 13 activity have a benefit for both the maternal and the baby outcome Plasma exchange should be initiated at the end of first trimester and repeated throughout the pregnancy and postpartum if necessary Pseudothrombocytopenia is often seen when anticoagulants such as EDTA are used when collecting blood.
They induce platelet aggregation and therefore false low platelet count. A peripheral blood smear is important for establishing the diagnosis the platelets are seen arranged in stacks. Disseminated intravascular coagulation DIC is characterized by the activation of the coagulation system, microvascular thrombus formation in different organs and multiple organ failure. Biochemically is defined by an increase of the PT, aPTT, thrombocytopenia, decreased fibrinogen, fibrin degradation product accumulation and the presence of D-dimers.
In pregnancy, DIC is caused by a number of causes, the most important being placental abruption, amniotic embolus and uterine rupture. Von Willebrand disease type IIb is a rare cause of thrombocytopenia in pregnancy. There is a qualitative defect of the von Willebrand factor inducing high affinity to the platelet receptor of glycoprotein 1b. Thrombocytopenia is explained by increased aggregation. Women with this condition may present with thrombocytopenia for the first time in pregnancy and platelets can drop to values below National Center for Biotechnology Information , U.
Journal List Maedica Bucur v. Maedica Bucur. Author information Copyright and License information Disclaimer. E-mail: panaitescu.
Copyright notice. This article has been cited by other articles in PMC. Keywords: thrombocytopenia, pregnancy, gestational thrombocytopenia Thrombocytopenia, defined as blood platelet count below Commune causes of thrombocytopenia in pregnancy are presented in Table 1.
Open in a separate window. Table 1. Immune thrombocytopenic purpura is not an indication for caesarean delivery 3,9. Conflict of interests: none declared. Financial support: none declared. Proceedings in Obstetrics and Gynecology. N Engl J Med. Ann Fr Anesth Reanim. Inflamm Bowel Dis.
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